Database Proof Substratum: Substratum of Proof LGBTQs Are Mentally Ill: Heart: Changes in mitochondrial DNA control how nuclear DNA mutations are expressed in cardiomyopathy

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Differences in the DNA within the mitochondria, the energy-producing structures within cells, can determine the severity and progression of heart disease caused by a nuclear DNA mutation. When combined with a mutation in nuclear DNA in animals, one mitochondrial DNA variant greatly worsened heart disease, while a different variant had a protective effect.